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Expression of mitochondria-related genes is elevated in overfeeding-induced goose fatty liver
2017/2/13 15:26:05 浏览次数:417
Expression of mitochondria-related genes is elevated in overfeeding-induced goose fatty liver
e
 
Abstract:
  Mitochondrion, the power house of the cell, is an important organelle involving in energy homeostasis. Change in mitochondrial mass and function may lead to metabolic disorders. Previous studies indicate that mitochondrial mass loss and dysfunction are associated with non-alcoholic fatty liver disease (NAFLD) in human and mouse.However, it is unclear whether mitochondrial genes are involved in the development of goose fatty liver. To address this, we determined the response of goose mitochondrial genes to overfeeding and other fatty liverrelated factors (e.g., hyperinsulinemia, hyperglycemia, and hyperlipidemia).
 
Acknowledgments:
  This study was financially supported by the National Nature Science Foundation of China (Beijing, China) to D.G. (31372298) and T.G.(31472086), the Priority Academic Program Development of Jiangsu Higher Education Institutions to both D.G. and T.G., Jiangsu Agriculture Science and Technology Innovation Fund (Jiangsu, China; grant no.CX(12)2033) to D.G.
 
References:
  1、Arany, Z., He, H., Lin, J., Hoyer, K., Handschin, C., Toka, O., Ahmad, F., Matsui, T., Chin, S.,
Wu, P.H., Rybkin, I.I., Shelton, J.M., Manieri, M., Cinti, S., Schoen, F.J., Bassel-Duby, R.,
Rosenzweig, A., Ingwall, J.S., Spiegelman, B.M., 2005. Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.Cell Metab. 1, 259–271.
 
文章链接:
  http://www.ncbi.nlm.nih.gov/pubmed/?term=Expression
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